Highly Convergent Straightforward Stereoselective Synthesis of (+)-C(9a)-Epiepiquinamide
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چکیده
منابع مشابه
A straightforward stereoselective synthesis of D- and L-5-hydroxy-4-hydroxymethyl-2-cyclohexenylguanine.
A novel and facile synthesis of 5-hydroxy-4-hydroxymethyl-2-cyclohexenylguanine 1 is described. The key steps involve a Diels-Alder reaction of ethyl (2E)-3-acetyloxy-2-propenoate 2 as dienophile with Danishefsky's diene 3 to build up the six-membered ring skeleton, a Fraser-Reid reductive rearrangement of the adduct using LiAlH(4), and base-moiety introduction using a Mitsunobu reaction. Optic...
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ژورنال
عنوان ژورنال: HETEROCYCLES
سال: 2018
ISSN: 0385-5414
DOI: 10.3987/com-18-s(t)66